Baran試劑，二烷基亞磺酸鋅鹽，可以直接對雜環(huán)芳烴C-H鍵進行官能團化?，F(xiàn)在很多Baran試劑都可以買到。6,7
反應機理
一種機理如下，形成CF3自由基參與反應。5
另外一種反應速率完全不同的機理也被觀察到，此機理現(xiàn)在還在研究階段。10
反應實例
咖啡因的二氟甲基化。
Baran試劑對喹啉的兩個氫連續(xù)進行官能團化。
利用Langlois試劑（三氟甲烷亞磺酸鈉）進官能團化。
參考文獻
1. Tordeux, M.; Langlois, B.; Wakselman, C. J. Chem. Soc., Perkin Trans. 1 1990,2293–2299.
2. Langlois, B. R.; Laurent, E.; Roidot, N. Tetrahedron Lett. 1991, 32, 7525–7528.
3. Clavel, J. L.; Langlois, B.; Laurent, E.; Roidot, N. Phosphorus, Sulfur, and Silicon 1991, 58, 463–466.
4. Kino, T.; Nagase, Y.; Ohtsuka, Y.; Yamamoto, K.; Uraguchi, D.; Tokuhisa, K.;
Yamakawa, T. J. Fluorine Chem. 2010, 131, 98–105.
5. Ji, Y.; Brueckl, T.; Baxter, R. D.; Fujiwara, Y.; Seiple, I. B.; Su, S.; Blackmond, D. G.; Baran, P. S. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 14411–14415. Phil S. Baran is currently a Professor in the Department of Chemistry at The Scripps Research Institute and Member of The Skaggs Institute for Chemical Biology. He was born in New Jersey in 1977, received his B.S. in chemistry from NYU in 1997, his Ph.D. at The Scripps Research Institute in 2001 (NSF fellow with K.C. Nicolaou), and from 2001–2003 he was an NIH postdoctoral fellow at Harvard in the laboratory of E. J. Corey. He has published over 120 scientific articles (H-Factor = 40) and has recently released a book in heterocyclic chemistry. His laboratory is focused on the invention of new reactions of broad utility and synthesizing complex natural products in a scalable, economic fashion. He recently won the John D. and Catharine T. MacArthur award. 【Phil S. Baran現(xiàn)任斯克利普斯研究所教授，斯卡格化學生物學研究所成員。他1977年出生于新澤西州，1997年獲得紐約大學的化學學士學位，2001年在斯克利普斯研究所獲得Ph.D.（在美國全國衛(wèi)生基金會與 K.C. Nicolaou是同事）。2001年到2003年在哈佛大學E. J. Corey的實驗室讀美國國立衛(wèi)生研究院博士后。他發(fā)表了超過120篇學術(shù)論文（H因子=40），最近還出版了一本雜環(huán)化學方面的書。他的實驗室主要研究方向是開發(fā)新反應的更廣的應用領域和利用更容易操作的成本低得新方法合成復雜的天然產(chǎn)物。他最近獲得了John D. and Catharine T. MacArthur獎?！?/p>
6. Fujiwara, Y.; Dixon, J. A.; Rodriguez, R. A.; Baxter, R. D.; Dixon, D. D.; Collins, M.R.; Blackmond, D. G.; Baran, P. S. J. Am. Chem. Soc. 2012, 134, 1494–1497.
7. Fujiwara, Y.; Dixon, J. A.; O’Hara, F.; Funder, E. D.; Dixon, D. D.; Rodriguez, R. A.; Baxter, R. D.; Herle, B.; Sach, N.; Collins, M. R.; Ishihara, Y.; Baran, P. S. Nature 2012, 492, 95–99.
8. Zhou, Q.; Ruffoni, A.; Gianatassio, R.; Fujiwara, Y.; Sella, E.; Shabat, D.; Baran, P. S. Angew. Chem. Int. Ed. 2013, 52, 3949–3952
9. O’Hara, F.; Baxter, R. D.; O’Brien, A. G.; Collins, M. R.; Dixon, J. A.; Fujiwara, Y.; Ishihara, Y.; Baran, P. S. Nature Protocols 2013, 8, 1042–1047.
10. Baxter, R. D.; Blackmond, D. G. Tetrahedron 2013, 69, 5604–5608.
11. O’Hara, F.; Blackmond, D. G.; Baran, P. S. J. Am. Chem. Soc. 2013, 135, 12122–12134.
編譯自：J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, Baran reagents，page 18-20.
